Document 1978
 DOCN  M94A1978
 TI    Predicting depression in HIV disorder. HNRC Group.
 DT    9412
 AU    Atkinson JH; Patterson TL; Chandler JL; Grant I; Sciolla A; University
       of California San Diego, Department of Psychiatry; (0603), UCSD School
       of Medicine, La Jolla 92093-0603.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):408 (abstract no. PD0238). Unique
       Identifier : AIDSLINE ICA10/94370597
 AB    OBJECTIVE: To determine two year risk and predictors of major depression
       in human immunodeficiency virus (HIV) infected (HIV+) men and
       seronegative (HIV-) controls. METHODS: HIV+ (N = 136) and HIV- (N = 44)
       men participating in a longitudinal cohort study were examined annually
       for personal and family history of mood disorder (Structured Clinical
       Interview for DSM-III-R [SCID]; Family History RDC), neuropsychological
       (NP) status, magnetic resonance imaging (MRI), coping (Ways of Coping),
       and marked life adversity (Brown & Harris). Likelihood of major
       depression was computed by survival analysis and predictors were
       determined from a Cox proportional hazards model. RESULTS: Kaplan-Meier
       plot for time to major depression indicated overall (HIV+ and HIV-) risk
       of 7% for each six-month interval on study. Time to episode of
       depression was related to premorbid history of major depression (logrank
       test, p < .001) and avoidant coping (p < .01) with life circumstances in
       the six months preceding the depressive episode, but not to serostatus,
       NP or MRI abnormality, or family history or life adversity. The two
       years cumulative risk was 48% for those with past history vs. 19% for
       those without prior major depression. CONCLUSION: Careful psychiatric
       history-taking and coping assessment is crucial to identifying high risk
       for mood disorders in HIV.
 DE    Comparative Study  Depression/*EPIDEMIOLOGY  Depressive
       Disorder/*EPIDEMIOLOGY  Human  HIV Infections/*PSYCHOLOGY  *HIV
       Seronegativity  HIV Seropositivity/*PSYCHOLOGY  Male  Neuropsychological
       Tests  Probability  Prognosis  Proportional Hazards Models  Risk Factors
       Survival Analysis  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).